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Identifying Adult Stem Cells Using Cre-Mediated Lineage …
https://pubmed.ncbi.nlm.nih.gov/26840226/
Identifying Adult Stem Cells Using Cre-Mediated Lineage Tracing. Lineage-tracing has been used for decades to establish cell fate maps during development. Recently, with the advent of genetic lineage-tracing techniques (employing Cre-lox recombination), it has been possible to permanently mark progenitor/stem cell populations within somatic tissues.
Cre-mediated recombination in cell lineages that express …
https://pubmed.ncbi.nlm.nih.gov/15682389/
Initial characterization of the PR-Cre mouse underscores the utility of this model to precisely ablate floxed target genes specifically in cell lineages that express the PR. In the wider context of female reproductive tissue ontology, this model will be indispensable in tracing the developmental fate of cell lineages that descend from PR positive progenitors.
Lineage Tracing Mediated by Cre-Recombinase Activity
https://www.jidonline.org/article/S0022-202X(15)37063-9/pdf
In cells in the bulge cell lineage (green cells), the Cre-recombinase mediates the deletion of the loxP site–flanked stop codon in front of the reporter gene and thereby induces reporter gene expression. This permanent genetic modification is passed on to the cell progeny, independent of Cre expression, and facilitates tracing of the cell lineage.
Identifying Adult Stem Cells Using Cre-Mediated Lineage Tracing
https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/9780470151808.sc05a02s36
Abstract. Lineage-tracing has been used for decades to establish cell fate maps during development. Recently, with the advent of genetic lineage-tracing techniques (employing Cre-lox recombination), it has been possible to permanently mark progenitor/stem cell populations within somatic tissues. In addition, pulse-chase studies have shown that only stem …
Dual Cre and Dre recombinases mediate synchronized …
https://www.sciencedirect.com/science/article/pii/S0021925822004057
Cre-loxP system is a powerful tool for genetic lineage tracing and cell ablation studies . However, the degree of recombination in cells of Rosa26-reporter or Rosa26-iDTR mice varies significantly between different Rosa26 alleles used as readouts ( 31 , 33 ).
Genetic lineage tracing with multiple DNA recombinases: …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212637/
Site-specific recombinases, such as Cre, are a widely used tool for genetic lineage tracing in the fields of developmental biology, neural science, stem cell biology, and regenerative medicine. However, nonspecific cell labeling by some genetic Cre tools remains a technical limitation of this recombination system, which has resulted in data misinterpretation and led to …
The Theory and Practice of Lineage Tracing - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618107/
If lineage tracing is performed using GeneX-Cre, the cell origin of C cells cannot be determined unequivocally. On the other hand, if GeneX-CreER is used, one can selectively label only B cells (if Tamoxifen is applied at timepoint1) or only A cells (if low dosage Tamoxifen is applied at timepoint2 since there are much more A cells than B cells), thereby determining the exact cell …
Rosa26-targeted swine models for stable gene over …
https://pubmed.ncbi.nlm.nih.gov/24503648/
Rosa26-targeted swine models for stable gene over-expression and Cre-mediated lineage tracing. Rosa26-targeted swine models for stable gene over-expression and Cre-mediated lineage tracing Cell Res. 2014 Apr;24(4):501-4. doi: 10.1038/cr.2014.15. Epub 2014 Feb …
Enhancing the precision of genetic lineage tracing using …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913096/
Here we describe a new genetic lineage-tracing system that incorporates Dre-rox to enhance the precision of conventional Cre-loxP mediated lineage tracing. The Dre- rox recombination system permits rigorous control of potential unintentional Cre- lox P recombination, effectively circumventing the uncertainty of the cell-type specificity of Cre expression in lineage tracing.
Mouse Cre Models for the Study of Bone Diseases - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397767/
In addition, Cre-driver lines can be used for lineage tracing when crossed with reporter lines in which Cre-mediated recombination induces expression of a reporter such as lacZ or a fluorescent reporter . When using such Cre-loxP reporter models it is important to keep in mind that, because the Cre-mediated DNA recombination event is ...
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