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Fate tracing reveals the endothelial origin of …
https://pubmed.ncbi.nlm.nih.gov/19041779/
Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM) region of the midgestation embryo, but the cell type responsible for their emergence is unknown since critical hematopoietic factors are expressed in both the AGM endothelium and its underlying mesenchyme. ... Fate tracing reveals the endothelial origin of ...
Fate Tracing Reveals the Endothelial Origin of …
https://www.sciencedirect.com/science/article/pii/S1934590908005237
Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM) region of the midgestation embryo, but the cell type responsible for their emergence is unknown since critical hematopoietic factors are expressed in both the AGM endothelium and its underlying mesenchyme. Here we employ a temporally restricted genetic tracing ...
Fate Tracing Reveals the Endothelial Origin of …
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(08)00523-7
Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM) region of the midgestation embryo, but the cell type responsible for their emergence is unknown since critical hematopoietic factors are expressed in both the AGM endothelium and its underlying mesenchyme. Here we employ a temporally restricted genetic tracing strategy to selectively …
Fate tracing reveals the endothelial origin of …
https://www.cirm.ca.gov/about-cirm/publications/fate-tracing-reveals-endothelial-origin-hematopoietic-stem-cells
HSC capacity is exclusively endothelial, as ex vivo analyses demonstrate lack of VE-cadherin Cre induction in circulating and fetal liver hematopoietic populations. Moreover, AGM mesenchyme, as selectively traced via a myocardin Cre line, is incapable of hematopoiesis. Our genetic tracing strategy therefore reveals an endothelial origin of HSCs.
Fate tracing reveals the endothelial origin of …
https://europepmc.org/article/MED/19041779
VE-cadherin lineage labels the vascular and hematopoietic AGM population. As studies have demonstrated the expression of VE-cadherin within the endothelial and hematopoietic stem cells of the AGM (North et al. 2002; Fraser et al. 2003), we investigated whether these cells can be labeled and traced using a constitutive VE-cadherin Cre mouse …
Fate Tracing Reveals the Endothelial Origin of …
https://www.researchgate.net/publication/23554740_Fate_Tracing_Reveals_the_Endothelial_Origin_of_Hematopoietic_Stem_Cells
Here, we used single-cell full-length transcriptome data to construct an isoform-based transcriptional atlas of the murine endothelial-to-hematopoietic …
Hemogenic Endothelial Fate Mapping Reveals Dual …
https://pubmed.ncbi.nlm.nih.gov/29858009/
Hematopoiesis occurs in distinct waves. "Definitive" hematopoietic stem cells (HSCs) with the potential for all blood lineages emerge in the aorta-gonado-mesonephros, while "primitive" progenitors, whose potential is thought to be limited to erythrocytes, megakaryocytes, and macrophages, arise earli …
Supplemental Data Fate Tracing Reveals the …
https://www.cell.com/cms/10.1016/j.stem.2008.09.018/attachment/1f4a92e7-485c-4cfb-bbdf-0c874e681cb1/mmc1.pdf
Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells Ann C. Zovein, Jennifer J. Hofmann, Maureen Lynch, ... (E - erythroid, M - myeloid, B - B cell, T – T cell, HSC – hematopoietic stem cell), and further determining the βgal activity within the gated population (lower panels). (D) As the FDG βgal assay can contribute ...
Endothelial-to-haematopoietic transition: an update on …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490701/
Introduction. In vertebrate animals, a close relationship exists between haematopoietic cells and endothelial cells. Haematopoietic cells travel through endothelium-lined blood vessels; they migrate in and out of the blood stream via docking to and transversing the endothelial layer; and haematopoietic stem and progenitor cells (HSPCs) are regulated and …
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