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Isotope tracing assisted metabolic profiling: Application …
https://pubmed.ncbi.nlm.nih.gov/30567669/
Isotope-tracing facilitates the understanding of metabolic regulation in biological systems. Depending on the selection of tracers, some essential metabolites cannot be traced. A comprehensive understanding of the regulated pathways can only be achieved with focus beyond labeled metabolites.
isotopic tracer | chemistry | Britannica
https://www.britannica.com/science/isotopic-tracer
isotopic tracer, any radioactive atom detectable in a material in a chemical, biological, or physical system and used to mark that material for study, to observe its progress through the system, or to determine its distribution. An isotopic tracer must behave as does the material being studied, but, in addition, it must have some distinguishing property by which it can be detected in the …
[Isotopic tracing technique in quantitative analysis of …
https://pubmed.ncbi.nlm.nih.gov/25989681/
To delineate altered metabolic pathways in cancer cells, isotopic tracing technique provides a novel and holistic insight in metabolic switch under control of oncogenes and tumor suppressor genes. An array of chromatography coupled with mass spectrometry is the powerful tool to detect the isotope-labeled metabolites for unlocking the underlying biochemical reactions in cancer …
Isotopic Tracing - SSTE - UNIGE
https://www.unige.ch/sciences/terre/en/research/isotope-geochemistry-geochronology-and-thermochronology/isotopic-tracing/
The isotopic tracing unit at UNIGE offers the possibility of carrying out isotopic analyses in the frame of scientific collaborative projects. For this we require an economic contribution to cover the running costs of the labs. For a quote of prices of isotopic analyses please contact: Dr. Massimo Chiaradia (Senior Lecturer, MER)
Metabolomics and isotope tracing - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034115/
Isotopic tracers for measuring pathway activities. Open in a separate window Control of the nutrient environment is particularly important. For in vivo studies, this means close attention to feeding, fasting, and diet composition. For cell culture studies, it means special care in media selection and timing of media changes.
Metabolomics and Isotope Tracing - PubMed
https://pubmed.ncbi.nlm.nih.gov/29727671/
Metabolomics and Isotope Tracing Great strides have been made over the past decade toward comprehensive study of metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of many metabolites simultaneously. Tracking metabolite labeling from stable isotope tracers can in addition reveal pathway activities. …
Isotope tracing reveals glycolysis and oxidative …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045768/
The isotopic labeling patterns in metabolites extracted from blood and tumor tissue can then be used to infer aspects of metabolic activity within the tumor. This technique has been applied to human lung cancer 24 – 27, clear cell renal cell carcinoma 28 , glioma and brain metastases 29 .
Isotopic tracing reveals single-cell assimilation of a …
https://pubmed.ncbi.nlm.nih.gov/33953365/
Isotopic tracing reveals single-cell assimilation of a macroalgal polysaccharide by a few marine Flavobacteria and Gammaproteobacteria
Isotopic tracing of the impact of mobility on infectious …
https://pubmed.ncbi.nlm.nih.gov/23280256/
Isotopic tracing of the impact of mobility on infectious disease: The origin of people with treponematosis buried in hull, England, in the late medieval period Abstract Treponematosis has been one of the most studied and debated infectious diseases in paleopathology, particularly from the standpoint of its origin, evolution, and transmission.
Isotopic labeling - Wikipedia
https://en.wikipedia.org/wiki/Isotopic_labeling
An isotopic tracer, (also "isotopic marker" or "isotopic label"), is used in chemistry and biochemistry to help understand chemical reactions and interactions. In this technique, one or more of the atoms of the molecule of interest is substituted for an atom of the same chemical element , but of a different isotope (like a radioactive isotope used in radioactive tracing ).
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