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On target? Tracing zinc-finger-nuclease specificity
https://www.nature.com/articles/nmeth.1680
ZFNs are synthetic enzymes composed of a nonspecific nuclease domain and a customized zinc-finger array that specifies DNA binding 3. Upon dimerization of two ZFN subunits at the intended target ...
On target? Tracing zinc-finger-nuclease specificity.
https://www.ncbi.nlm.nih.gov/pubmed/21878917
On target? Tracing zinc-finger-nuclease specificity. Mussolino C(1), Cathomen T. Author information: (1)Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany. Comment on Nat Methods. 2011 Sep;8(9):765-70.
On target? Tracing zinc-finger-nuclease specificity
https://www.researchgate.net/publication/51606704_On_target_Tracing_zinc-finger-nuclease_specificity
Request PDF | On target? Tracing zinc-finger-nuclease specificity | In two independent studies, researchers experimentally test the cleavage specificity of zinc …
Revealing Off-Target Cleavage Specificities of Zinc Finger …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164905/
Introduction. Zinc finger nucleases (ZFNs) are enzymes engineered to recognize and cleave desired target DNA sequences. A ZFN monomer consists of a zinc finger DNA-binding domain fused with a non-specific FokI restriction endonuclease cleavage domain 1.Since the FokI nuclease domain must dimerize and bridge two DNA half-sites to cleave DNA 2, ZFNs are …
Zinc Finger Nuclease - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/zinc-finger-nuclease
Target site specificity is therefore determined by two zinc-finger DNA-binding domains, each of which consists of three or more tandem repeats of individual zinc fingers. Each individual zinc finger recognizes three base pairs (Beerli, Segal, Dreier, & Barbas, 1998), and a zinc-finger DNA-binding domain in total recognizes at least nine base pairs.
Revealing off-target cleavage specificities of zinc-finger …
https://www.nature.com/articles/nmeth.1670
An in vitro method for examining cleavage patterns of zinc-finger nucleases (ZFNs) identifies previously unknown off-target cleavage sites. Some of the sites are present in the human genome and ...
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